Almost 10 years after completion of the Human Genome Project in 2003, scientists are making progress toward the next major goal in applying the genetic information in that “Book of Life” in medicine, leaders of an international research effort are reporting. A package of the latest updates on the goals, organization and achievements of the Chromosome-Centric Human Proteome Project (C-HPP) appear in a special issue of ACS’ Journal of Proteome Research.